Paracetamol injection 750mg: overview

Paracetamol injection 750mg is an intravenous formulation of the common pain relief medication paracetamol (also known as acetaminophen). It is administered directly into the bloodstream for the treatment of acute moderate pain, as well as fever reduction.

The injection contains 750mg of paracetamol in each 10ml vial. When injected into the vein, paracetamol is absorbed rapidly and provides faster pain relief compared to oral tablets. Peak plasma concentrations are reached within 5-10 minutes after intravenous administration.

Paracetamol injection is suited for situations where oral administration is not ideal, such as before or after surgery, or when patients are unable to swallow. It allows for accurate dosing and the effects kick in quickly. The intravenous route also avoids first-pass metabolism in the liver, making it useful when rapid analgesia is required.

Overall, paracetamol injection provides an effective way to administer this common analgesic directly into the bloodstream for faster pain relief. The 750mg dosage in a single vial provides a high concentration designed for intravenous infusion over 15 minutes.

paracetamol inj 750mg

paracetamol inj 600mg

Uses of Paracetamol Injection 750mg

Paracetamol injection is commonly used for the treatment of mild to moderate pain, as well as fever reduction. Some of the main uses and indications include:

• Postoperative pain management - Paracetamol injection is often used to help manage pain after surgery. It can provide analgesia either alone or in combination with other pain medications such as opioids. The injection allows for controlled administration immediately after surgery.

• Cancer pain - For some types of cancer pain, especially mild to moderate, paracetamol injection may be used alone or with other analgesics to provide pain relief. It provides an alternative to opioid pain medications.

• Fever reduction - Paracetamol injection can help reduce fever in patients when administered intravenously or intramuscularly. It is an antipyretic agent.

• Headaches - Paracetamol injection can provide relief for tension headaches and other types of acute headaches when used appropriately.

• Musculoskeletal pain - From back pain to arthritis pain, paracetamol injection is sometimes used to help manage acute flare ups of musculoskeletal pain.

• Kidney stones or renal colic - Paracetamol may be used as an analgesic adjunct for the pain associated with kidney stones and obstruction in the urinary tract.

The intravenous route allows paracetamol to provide rapid analgesic and antipyretic effects compared to oral administration. It is an option for patients who may not be able to take oral medications.

paracetamol inj 750mg

paracetamol inj 600mg

Dosage of Paracetamol Injection 750mg

Paracetamol injection 750 is available in vials containing 750 mg of paracetamol. The recommended dosage is 15 mg/kg every 4 to 6 hours, with a maximum of 4 grams per day.

The dose should be adjusted based on the patient's weight. An adult weighing 50-60 kg would receive 500-750 mg every 4-6 hours. Children require a lower dose based on their weight - 15 mg/kg every 4 hours, up to 60 mg/kg per day.

It's important not to exceed 4 grams per day to avoid potential liver toxicity. Lower maximum doses apply for patients with liver dysfunction or malnutrition. Paracetamol injection should be used with caution in these groups.

The injection is given intravenously over 15 minutes. It provides rapid pain and fever relief compared to oral paracetamol which takes 30-60 minutes.IV paracetamol reaches peak plasma concentrations within 5 minutes of administration.

paracetamol inj 750mg

paracetamol inj 600mg

Administration of Paracetamol injection 750mg

Paracetamol injection is given as an intravenous infusion. The powder must be reconstituted with the appropriate diluent before administration.

To prepare the infusion:

• Remove the flip-off seal from the vial and wipe the top with an alcohol swab.

• Using a syringe, insert the provided diluent (typically sterile water, normal saline, or 5% dextrose) into the vial. Shake gently until the powder is fully dissolved.

• The standard concentration is 10mg/ml. So for a 750mg vial, 75ml of diluent should be used.

• After reconstitution, the solution should be clear. Inspect visually for particulate matter or discoloration. Discard if present.

• The required dose of the reconstituted solution can then be further diluted in an appropriate infusion solution like normal saline or 5% dextrose.

• The standard adult dose is 15mg/kg given over 15 minutes. This equates to 1ml/kg of the 10mg/ml solution over 15 minutes.

• For obese patients, dosing should be based on ideal body weight.

• The infusion line should be flushed thoroughly before and after administration.

Paracetamol injection is for intravenous infusion only. It should not be administered by IV push or IM injection. Careful adherence to preparation and administration guidelines can help reduce the risk of medication errors.

Contraindications of Paracetamol injection 750mg

Paracetamol injection should be avoided in the following situations:

• Known hypersensitivity to paracetamol or any of the excipients in the paracetamol formulation. Patients with a history of serious skin reactions to paracetamol should not receive paracetamol injection.

• Severe liver impairment or active liver disease. Paracetamol is extensively metabolized in the liver and can potentially cause further liver damage in patients with existing liver dysfunction. Caution is recommended even in mild-moderate hepatic impairment.

• Chronic alcoholism. Chronic alcoholics are at increased risk of paracetamol-induced hepatotoxicity even at therapeutic doses. Paracetamol injection is contraindicated in patients with a daily alcohol intake of 3 or more alcoholic drinks.

• Concomitant use of enzyme inducing drugs like barbiturates, carbamazepine, rifampicin etc. These can increase the production of hepatotoxic metabolites of paracetamol by inducing liver enzymes. The paracetamol dose may need to be reduced in such cases.

• Glucose-6-phosphate dehydrogenase (G6PD) deficiency. Paracetamol can cause hemolysis in patients with G6PD deficiency.

• Dehydration. There is an increased risk of paracetamol toxicity in dehydrated patients. Adequate hydration should be ensured before giving paracetamol injection.

• Malnutrition. Malnourished individuals are at higher risk of liver damage from paracetamol overdose. Caution is advised if giving paracetamol injection to malnourished patients.

In summary, paracetamol injection is contraindicated in patients with known hypersensitivity, severe hepatic impairment, chronic alcoholism, use of enzyme inducers, G6PD deficiency, dehydration and malnutrition. Caution should be exercised in patients with mild-moderate liver disease.

paracetamol inj 750mg

paracetamol inj 600mg

Paracetamol Injection 750mg Side Effects

Like all medications, paracetamol injection can cause side effects in some people. Most side effects are mild and temporary. However, some can be serious and require medical attention.

Common side effects of paracetamol injection include:

• Nausea or vomiting.

• Constipation.

• Headaches.

• Rash.

• Itching.

• Sweating.

• General feeling of discomfort or illness.

These side effects often go away within a few days after treatment ends. Let your doctor know if any side effect becomes severe or doesn't go away.

Rare but serious side effects include:

• Liver damage: High doses of paracetamol can cause liver toxicity and damage. Symptoms include yellowing of skin/eyes, dark urine, stomach pain, nausea, vomiting, and loss of appetite. Liver damage is possible even at recommended doses in some cases. Seek medical help immediately if you experience these symptoms.

• Low blood cell counts: Paracetamol may cause a decrease in blood cells that help fight infections and stop bleeding. This can increase the risk of infections or excessive bleeding. Consult your doctor if you develop symptoms like frequent infections, bruising/bleeding, weakness, pale skin, or fever.

• Severe skin reactions: In rare cases, paracetamol injection may cause serious skin reactions like Stevens-Johnson syndrome. Symptoms include painful red or purplish rash, blisters, peeling skin, fever, chills, aching muscles. Seek urgent medical care if you notice these symptoms.

Inform your doctor right away about any serious side effects after receiving paracetamol injection. Prompt treatment can help manage complications. Call emergency services if you experience signs of a life-threatening reaction like trouble breathing, chest tightness, or swelling of the face/throat. Serious side effects are rare when paracetamol is used correctly under medical supervision.

paracetamol inj 750mg

paracetamol inj 600mg

Paracetamol Injection 750mg Interactions

Paracetamol injection may interact with several other medications. It's important to inform your doctor of all drugs you are currently taking before receiving paracetamol injection.

Interactions with Other Drugs:

• Warfarin: Paracetamol can increase the anticoagulant effect of warfarin and increase the risk of bleeding. Close monitoring of INR is recommended.

• Isoniazid: Isoniazid can decrease the clearance of paracetamol, increasing its plasma concentration. Monitoring for hepatotoxicity is advised, and paracetamol dose may need reduction.

• Phenytoin and Carbamazepine: These anticonvulsants can increase the hepatotoxicity of paracetamol by increasing its metabolite production. Using paracetamol with phenytoin or carbamazepine requires close monitoring.

• Rifampicin: Rifampicin increases the clearance of paracetamol, possibly decreasing its efficacy. Dose adjustment of paracetamol may be needed.

• Probenecid: Probenecid decreases the clearance of paracetamol, increasing its plasma levels. Paracetamol dose reduction is recommended.

• Oral Contraceptives: Paracetamol may decrease the efficacy of oral contraceptives. Additional non-hormonal birth control methods should be used.

• Cholestyramine: Cholestyramine can decrease paracetamol absorption and plasma levels. Paracetamol should be taken at least 1 hour before or 4 hours after cholestyramine.

It's important to inform healthcare providers about all current medications before receiving paracetamol injection to allow for monitoring and dosage adjustments if needed. Paracetamol may potentially interact with many other drugs as well.

paracetamol inj 750mg

paracetamol inj 600mg

Paracetamol Injection 750mg Warnings

Paracetamol injection should be used with caution in patients with the following conditions:

Liver disease - Paracetamol is metabolized by the liver. Patients with hepatic disease may require a reduced dose. Monitor liver function.

Long-term alcohol use - Drinking alcohol is more damaging to the liver and increases the risk of liver disease. Use caution and monitor liver function.

Malnutrition - Malnutrition may increase the risk of acetaminophen deficiency due to glutathione deficiency. Use low doses and monitor.

Renal failure - Paracetamol metabolites are eliminated by the kidneys. In kidney failure, metabolites accumulate. Reduce dose based on severity and monitor.

Elderly Patients - Hepatotoxicity may occur in elderly patients. Use low doses and monitor.

Phenylketonuria - Paracetamol injection contains phenylalanine. Be careful in patients with phenylketonuria.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency - Patients with G6PD deficiency may be at increased risk for hemolysis. Be careful.

Patients should be advised to consult a physician if they develop signs or symptoms of liver damage, rash, or allergic reaction while taking paracetamol. If this happens, stop using acetaminophen.

Paracetamol Injection Overdose

Paracetamol overdose can occur when an overdose of the drug is taken, either accidentally or intentionally. The daily adult dose is 4 grams (4000 mg). Taking too much can cause liver damage.

Other Symptoms:

Nausea, vomiting, and abdominal pain occur within the first 24 hours.

Liver injury begins 1 to 2 days after overdose. Symptoms include jaundice (yellowing of the skin and eyes), dark urine, lighter stools, and elevated liver enzymes.

Acute liver failure may occur 2-4 days after treatment. Symptoms include confusion, drowsiness, coma, and death.

Other symptoms include sweating, hypoglycemia, metabolic acidosis, and renal disease.

paracetamol inj 750mg

paracetamol inj 600mg

Paracetamol Injection 750 mg Key Features

Paracetamol Injection 750 mg is a form of paracetamol (also known as acetaminophen) that relieves mild to moderate pain and reduces fever.

It works by inhibiting the synthesis of prostaglandins in the central nervous system, helping to reduce pain and regulate body temperature.

Injectable paracetamol is particularly effective if oral administration is not possible, such as in patients with nausea, vomiting, or dysphagia.

The adult dose is 1 g every 4-6 hours, up to 4 g per day. It is injected into the bloodstream for 15 minutes.

Side effects are rare except for fever, sweating, nausea, and high blood pressure. The risk of liver damage is lower than with oral paracetamol.

Use with caution in patients with liver disease. Concomitant use of other drugs containing acetaminophen should be avoided to prevent overdose.

Paracetamol injection is an alternative method of controlling pain and fever when the oral route is not suitable. It is safe and effective to use under medical supervision.

What is Paracetamol injection 750mg?

Paracetamol injection 750mg is an intravenous formulation of the common pain relief medication paracetamol (also known as acetaminophen). It is administered directly into the bloodstream for the treatment of acute moderate pain, as well as fever reduction.

The injection contains 750mg of paracetamol in each 10ml vial. When injected into the vein, paracetamol is absorbed rapidly and provides faster pain relief compared to oral tablets. Peak plasma concentrations are reached within 5-10 minutes after intravenous administration.

Paracetamol injection is suited for situations where oral administration is not ideal, such as before or after surgery, or when patients are unable to swallow. It allows for accurate dosing and the effects kick in quickly. The intravenous route also avoids first-pass metabolism in the liver, making it useful when rapid analgesia is required.

Overall, paracetamol injection provides an effective way to administer this common analgesic directly into the bloodstream for faster pain relief. The 750mg dosage in a single vial provides a high concentration designed for intravenous infusion over 15 minutes.

What are Uses of Paracetamol Injection 750mg?

Paracetamol injection is commonly used for the treatment of mild to moderate pain, as well as fever reduction. Some of the main uses and indications include:

• Postoperative pain management - Paracetamol injection is often used to help manage pain after surgery. It can provide analgesia either alone or in combination with other pain medications such as opioids. The injection allows for controlled administration immediately after surgery.

• Cancer pain - For some types of cancer pain, especially mild to moderate, paracetamol injection may be used alone or with other analgesics to provide pain relief. It provides an alternative to opioid pain medications.

• Fever reduction - Paracetamol injection can help reduce fever in patients when administered intravenously or intramuscularly. It is an antipyretic agent.

• Headaches - Paracetamol injection can provide relief for tension headaches and other types of acute headaches when used appropriately.

• Musculoskeletal pain - From back pain to arthritis pain, paracetamol injection is sometimes used to help manage acute flare ups of musculoskeletal pain.

• Kidney stones or renal colic - Paracetamol may be used as an analgesic adjunct for the pain associated with kidney stones and obstruction in the urinary tract.

The intravenous route allows paracetamol to provide rapid analgesic and antipyretic effects compared to oral administration. It is an option for patients who may not be able to take oral medications.

Product Specifications:

paracetamol inj 750mg

SKU“stock keeping unit”:2024.par17501.

gtin14:20231111001004

Price:0.99 - 1.99$.

Price Currency: USD

Price Valid Until:"2026-11-20

paracetamol inj 750mg

paracetamol inj 750mg

paracetamol inj 750mg

Volume:1ml.

Dosage:750mg.

Active Ingredients:paracetamol.

Specifications:BP；USP.

Packaging:Amp,5；10.