Paracetamol injection 500mg: overview

Paracetamol 500 mg Injection is an intravenous version of the common pain reliever paracetamol (also known as acetaminophen).

is prescribed to treat mild to severe pain and reduce fever. Paracetamol injection works by blocking the synthesis of prostaglandins in the brain and spinal cord that transmit pain signals. It crosses the blood-brain barrier, works intensively, and lowers body temperature.

Paracetamol Injection is used when oral administration is not possible, such as before or after surgery, or when the patient is nauseated or vomiting. The analgesic and antipyretic effects occur more quickly than oral paracetamol. Intravenous administration increases bioavailability and avoids hepatic metabolism.

Hospitals and clinics administer paracetamol when needed to provide rapid, strong analgesia/fever reduction. It is usually given before and after surgery to relieve pain and fever.

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Acetaminophen Injection Uses 500mg

Acetaminophen Injection is used to treat mild to moderate pain and reduce fever. Doctors may prescribe paracetamol injections for the following reasons:

Post-operative pain management - Paracetamol injections are often used after surgery to relieve severe pain and avoid opioid-induced illness. It helps provide effective pain relief when patients are unable to take oral medications.

Reduce fever - Paracetamol injections can quickly reduce fevers such as infections, inflammation or immune reactions. It is an antipyretic.

Migraines and Headaches - For severe headaches or migraines, injectable paracetamol can provide immediate relief when oral paracetamol doesn't work.

Musculoskeletal Pain - Paracetamol may be given by injection to treat severe pain caused by arthritis, rheumatism, arthritis and other musculoskeletal conditions (injections are used as oral medications).

Kidney or gallstones - Some doctors prescribe injectable paracetamol as part of multidisciplinary treatment for kidney or gallstones.

Cancer Complications - Treatment with paracetamol may be used when oral administration is not possible or possible.

The main reason doctors choose paracetamol injection over other pain relievers is its low and no side effects compared to nonsteroidal anti-inflammatory drugs and opioids. Fever and pain can be effective if treated properly.

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Dosage Information

Paracetamol injection is usually given intravenously. The recommended dose for adults is 1 gram every 4 to 6 hours, increasing by 4 grams over 24 hours.

In elderly patients, patients with liver disease, and the elderly weighing less than 50 kg, it is recommended to reduce the dose to 500-1000 mg every 4-6 hours. The maximum dose should not exceed 60 mg/kg per day.

Paracetamol injections are not recommended for children under 10 kg. For children weighing between 10-50 kg, the recommended dose is 15 mg/kg, with a maximum of 60 mg/kg per day.

As the patient improves, the duration of the dose should be increased. Intravenous paracetamol should be administered over 15 minutes and diluted in intravenous fluids if necessary.

Paracetamol should not be administered to patients with severe liver disease due to hepatotoxicity. Patients with renal impairment may also require a dose reduction.

Healthcare providers should monitor liver function and watch for signs of overdose, including nausea, vomiting, and right-sided abdominal pain.

paracetamol inj 500mg

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Administration

Paracetamol injection is administered intravenously, usually by intravenous injection. It should be provided by a doctor or nurse in a hospital or clinic.

The adult dose is 1 g administered slowly over 15 minutes every 4-6 hours, up to a maximum of 4 g daily. It is supplied as a ready-to-use solution in 10mL vials at a concentration of 10mg/mL. Before intravenous administration, the required dose is diluted with 50-100 mL of compatible diluent.

Paracetamol Injection has been shown to be compatible with common infusion solutions such as normal saline, 5% dextrose, and lactated Ringer's solution. But it should not be mixed with other drugs at the same time. Acetaminophen injection should be administered on a separate infusion schedule.

Vital signs such as blood pressure, heart rate, respiration, and body temperature should be monitored during the infusion. All infusion-related procedures should be read immediately.

paracetamol inj 500mg

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Paracetamol Injection 500mg Side Effects

Paracetamol Injection can cause severe pain when taken internally. Analgesia occurs within 5 to 10 minutes of administration.

The protective effect of a single dose of paracetamol usually lasts for 4 to 6 hours, after which the analgesic effect diminishes and the next dose can be given if needed.

The most common side effects of acetaminophen injection are:

Nausea and vomiting - up to 1 in 10 people may experience this. Nausea may be worse when acetaminophen is given rapidly through an IV.

Inhalation - Redness of the face and neck is a common side effect.

Sweating - Sometimes heavy sweating occurs immediately after an injection.

Hypotension - A slight drop in blood pressure immediately after a paracetamol injection. This is only temporary.

Injection site pain - Pain, stinging, or burning sensation at the injection site. These are simple and go quickly.

Side effects are rare. An allergic reaction to acetaminophen injections is unlikely, but may cause symptoms such as flushing, itching, wheezing, and difficulty breathing. In some cases, liver damage occurs as a result of taking too much paracetamol.

Precautions

Injectable paracetamol, like oral paracetamol, should be used with caution in patients with:

Hepatic impairment or severe liver disease - Paracetamol is metabolized by the liver, thereby increasing the risk of paracetamol accumulation and liver damage. . . Low dosage is recommended.

Drinking alcohol - Drinking alcohol can activate liver enzymes and increase the metabolism of acetaminophen, making it toxic. This increases the risk of liver disease. Limit alcohol intake while taking acetaminophen.

Renal Impairment - In renal impairment, the production of paracetamol metabolites is reduced and the risk of accumulation is increased. Depending on renal function, dose reduction may be necessary.

G6PD Deficiency - Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency are at increased risk of red blood cell damage when taking acetaminophen.

Pregnancy and Breastfeeding - Paracetamol has been shown to be safe during pregnancy when used at normal doses. Please consult your doctor before use. Caution is recommended during long-term use during pregnancy.

Elderly patients - The elderly are more susceptible to poisoning. Consider using lower doses in elderly or frail patients.

Paracetamol Injection should not be used in patients with:

Known hypersensitivity or intolerance to paracetamol

Severe acute illness

Possible drug interactions:

Anticonvulsant paracetamol

Check carefully after injecting paracetamol. Health care providers should perform laboratory testing and evaluate toxicity and side effects.

Laboratory examinations and tests

Liver examinations should be performed before and during treatment. High doses of paracetamol can cause liver damage.

Renal function and electrolytes should be monitored because acetaminophen is broken down by the kidneys. Kidney damage increases the risk of acetaminophen ingestion and liver damage.

In critically ill patients, blood paracetamol concentrations should be determined. The therapeutic dose range is 10-20 mcg/mL. Higher levels indicate increased inflammation and a higher risk of liver disease.

Comparisons with Other Treatments

Paracetamol injection is most commonly used for the treatment of fever and mild-to-moderate pain. It can be compared to other common medications used for these purposes:

• NSAIDs (non-steroidal anti-inflammatory drugs) - NSAIDs like ibuprofen (Advil, Motrin) and naproxen (Aleve) are also used to treat fever and pain. Unlike paracetamol, NSAIDs also have anti-inflammatory effects. However, NSAIDs have more potential side effects like stomach ulcers or bleeding, high blood pressure, kidney problems, and increased risk of heart attack or stroke. Paracetamol is usually preferred over NSAIDs in people with these conditions.

• Opioid pain medications - Opioids like morphine, oxycodone, and codeine are stronger pain medications sometimes used for moderate-to-severe pain. While more potent for pain relief, opioids have risks of addiction, overdose, and side effects like drowsiness, constipation, and slowed breathing. Paracetamol is not addictive and is safer for most people.

• Acetaminophen oral tablets - Paracetamol injection provides faster pain relief compared to oral acetaminophen tablets. However, oral tablets may be appropriate for milder pain or fever. The injection would be used when a patient cannot take oral medication or rapid onset is needed.

• IV morphine - For severe acute pain like trauma, heart attacks, or postoperative pain, IV morphine may be used instead of paracetamol injection. However, morphine has more side effects and monitoring requirements. Paracetamol injection can be used in combination with opioids like morphine to enhance pain control.

So in summary, paracetamol injection offers fever/pain reduction without risks of NSAID side effects, opioid addiction, or oral medication issues. It can be used alone or combined with other agents depending on the clinical scenario.

What is Paracetamol Injection 500mg?

Paracetamol 500 mg Injection is an intravenous version of the common pain reliever paracetamol (also known as acetaminophen).

is prescribed to treat mild to severe pain and reduce fever. Paracetamol injection works by blocking the synthesis of prostaglandins in the brain and spinal cord that transmit pain signals. It crosses the blood-brain barrier, works intensively, and lowers body temperature.

Paracetamol Injection is used when oral administration is not possible, such as before or after surgery, or when the patient is nauseated or vomiting. The analgesic and antipyretic effects occur more quickly than oral paracetamol. Intravenous administration increases bioavailability and avoids hepatic metabolism.

Hospitals and clinics administer paracetamol when needed to provide rapid, strong analgesia/fever reduction. It is usually given before and after surgery to relieve pain and fever.

What is paracetamol used for?

Symptoms of Poisoning

Patients receiving paracetamol injections should be monitored for:

Nausea, vomiting, sweating and loss of appetite - the first symptoms of paracetamol poisoning.

Abdominal pain, diarrhea, yellowing of skin/eyes - symptoms of liver disease.

Changes in urine output, blood in urine - signs of kidney damage.

Confusion, sleep, unconsciousness.

Shortness of breath, blue lips/nails - lung/heart disease risk.

If symptoms of poisoning occur, paracetamol injection should be stopped immediately and liver function should be monitored. Acetylcysteine can be taken to prevent liver damage. If symptoms are severe, seek emergency medical care.

When to Seek Medical Advice?

Paracetamol injection is generally safe when used as directed. However, there are some signs and symptoms to look out for that may indicate a more serious reaction.

Signs to Look Out For

Contact your doctor immediately if you experience any of the following after receiving paracetamol injection:

• Rash, hives, or itching

• Swelling of the face, throat, tongue, lips, or eyes

• Hoarseness or difficulty breathing or swallowing

• Unusual bruising or bleeding

• Signs of liver problems like dark urine, yellowing eyes/skin, stomach pain, or nausea

These could be signs of an allergic reaction or other adverse effect that requires prompt medical care. Do not ignore or wait to see if symptoms resolve on their own.

When to Call a Doctor?

In addition to the above symptoms, call your doctor if you experience:

• Persistent nausea, vomiting, or loss of appetite

• Stomach pain that does not go away

• Headaches that do not resolve after treatment

• Ongoing fever or flu-like symptoms

• Depression or confusion

• Ringing in the ears or changes in hearing

• Seizures

Unrelenting side effects or new symptoms that arise during or after treatment with paracetamol injection need medical evaluation. Do not try to self-manage side effects without speaking to your healthcare provider.

Calling a doctor promptly at the first sign of a potential reaction or side effect can help prevent complications. Follow your provider's recommendations regarding any symptoms after receiving paracetamol injection.

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Product Specifications:

paracetamol inj 500mg

SKU“stock keeping unit”:2024.par15001.

gtin14:20231111001002

Price:0.95 - 1.99$.

Price Currency: USD

Price Valid Until:"2026-11-20

paracetamol inj 500mg

paracetamol inj 500mg

paracetamol inj 500mg

Volume:1ml.

Dosage:500mg.

Active Ingredients:paracetamol.

Specifications:BP；USP.

Packaging:Amp,5；10.