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Paracetamol injection 600mg: overview

Paracetamol injection 600mg is an intravenous formulation of the common pain reliever and fever reducer paracetamol, also known as acetaminophen.

The injection comes in vials containing 600mg of paracetamol per 10mL solution. It is administered directly into the bloodstream through intravenous infusion.

Paracetamol injection 600mg provides a higher concentration and faster delivery method compared to oral paracetamol tablets. It allows patients who are unable to take medications by mouth, or require urgent symptom relief, to benefit from paracetamol's effects.

The injection is used for management of mild to moderate pain, and reduction of fever, when the intravenous route is clinically indicated. As an analgesic and antipyretic, it works by inhibiting prostaglandin synthesis in the body's central nervous system to block pain and reduce fever.

Paracetamol injection 600mg delivers the pain and fever relieving effects of paracetamol rapidly due to its IV administration. It provides an alternative delivery method when timely relief is needed and oral administration is not suitable.

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Uses and Benefits

Paracetamol injection 600mg is primarily used for providing fast and effective pain relief as well as reducing fever. It has several advantages over other pain relievers:

• Provides rapid onset of action, with pain relief starting within 5-10 minutes after intravenous administration. This is faster than oral paracetamol tablets.

• Effective for treating acute moderate to severe pain, such as post-operative pain, headache, backache, arthritis, toothache, sore throat, and muscle aches. Can provide adjunct pain relief along with opioids.

• Reduces elevated body temperature in feverish conditions. Can be used to treat fever arising from infections, inflammation, malignancy or other conditions.

• Better safety profile compared to other non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, as it has minimal adverse effects on stomach, intestines, liver and kidneys.

• Does not cause bleeding problems like aspirin, so can be safely used in people with clotting disorders or risk of bleeding.

• Not a narcotic, so lacks the addiction potential or abuse liability of opioid painkillers like morphine or codeine.

• Fast absorption allows rapid therapeutic action for acute pain or fever episodes. Does not need to be taken regularly for sustained effect.

• Can be used in all age groups including elderly, children and even infants above 10 weeks old. Safe in pregnancy and breastfeeding.

So in summary, intravenous paracetamol 600mg provides rapid, effective and safe symptomatic relief for both pain and fever, with advantages over similar analgesic medications. It is particularly useful when fast onset of action is required.

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How does Paracetamol Injection 600mg work?

Paracetamol injection 600mg works by inhibiting the synthesis of prostaglandins in the central nervous system and peripherally, which helps reduce pain and fever. It does this by inhibiting cyclooxygenase (COX) enzymes, which are responsible for prostaglandin synthesis.

Unlike NSAIDs like ibuprofen which inhibit both COX-1 and COX-2 enzymes, paracetamol mainly acts on the COX-2 enzyme involved in pain and inflammation. This makes it effective for pain relief while having a lower risk of gastrointestinal side effects compared to NSAIDs.

Paracetamol also activates cannabinoid receptors in the brain which can modulate pain transmission. And it indirectly activates descending serotonergic pathways in the brainstem that also inhibit pain signals.

So in summary, paracetamol provides analgesic and antipyretic effects through multiple mechanisms, including inhibiting COX-2 enzymes, activating cannabinoid receptors, and modulating serotonin pathways. This multi-modal action provides effective pain relief comparable to NSAIDs, but with a more favorable side effect profile.

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Administration and dosage

Paracetamol injection is administered either as an intravenous (IV) infusion or intramuscular (IM) injection.

Recommended dosage:

• For IV infusion, the recommended dose for adults is 1g paracetamol (10ml of injection) every 4-6 hours, up to a maximum of 4g per day.

• For IM injection, adults may receive 600-1000mg paracetamol every 4-6 hours, up to 4g per day maximum.

• Dosage needs to be reduced in patients with liver impairment.

Administration methods

IV infusion is the preferred method of administration for paracetamol injection, as it allows for faster pain relief compared to IM injection. The infusion is administered over 15 minutes.

IM injection can be used when IV access is not available. It should be injected deep into the muscle mass.

Special considerations:

• Paracetamol injection dosage may need adjustment in elderly patients, as well as those who are underweight or have chronic alcoholism, due to differences in metabolism.

• Caution is required in patients with liver or kidney dysfunction. Dose reduction may be necessary.

• Paracetamol injection is not recommended for use in children under 10 years old.

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Paracetamol Injection 600mg Side Effects

Common Side Effects:

Paracetamol injection is generally well tolerated when used as directed. The most common side effects are:

• Nausea or vomiting

• Sweating

• Loss of appetite

• Feeling lightheaded or dizzy

• Skin rash

These side effects are usually mild and go away on their own. If they persist or become bothersome, consult your doctor.

Rare but Serious Side Effects:

In rare cases, paracetamol injection can cause potentially fatal skin reactions such as Stevens-Johnson syndrome. Seek medical attention immediately if you experience any of these symptoms while taking paracetamol injection:

• Blistering or peeling skin rash

• Red irritated eyes

• Sores in mouth, throat, nose or eyes

• Fever and chills

Liver damage is another rare but serious risk, especially at high doses or with long-term use. Stop using paracetamol and call your doctor if you have dark urine, stomach pain, nausea, vomiting, loss of appetite, or yellowing eyes/skin.

Who Should Not Take It

You should not use paracetamol injection if you:

• Have had an allergic reaction to paracetamol or other pain relievers in the past

• Have severe liver or kidney disease

• Drink more than 3 alcoholic beverages per day

• Are taking other drugs containing paracetamol

Paracetamol injection is also not recommended for children younger than 10 years old without medical advice. Tell your doctor about any medical conditions and medications you take before using paracetamol injection.

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Interactions

Paracetamol injection 600mg can interact with several medications and substances. Patients and medical providers should be aware of the following interactions:

Drug Interactions:

• Anticoagulant medications like warfarin may have increased effects when taken with paracetamol. Paracetamol can increase the anticoagulant effect, increasing the risk of bleeding.

• Isoniazid levels may decrease when taken with paracetamol, making isoniazid less effective. Separating the dosing times may help avoid this interaction.

• Medications broken down by the liver can potentially build up with paracetamol since it is metabolized by the liver. This includes medications like anticonvulsants, antidepressants, antihistamines, and others. The dose of these medications may need adjusted.

Food Interactions:

• Alcohol can increase the risk of liver toxicity when consumed with paracetamol. Intake should be avoided or limited.

• Grapefruit juice may slow the clearance of paracetamol, increasing its effects and side effects. Avoid taking paracetamol with grapefruit juice.

Supplement Interactions:

• Vitamin K supplements may interact with paracetamol in a similar way to anticoagulant medications. The combined effect can increase risk of bleeding.

• St. John's Wort can affect liver enzymes that break down paracetamol, causing it to build up. Use caution when combining.

• Multivitamins that contain vitamin K, vitamin C, or other antioxidants may potentially interact with paracetamol. Separate dosing times can help minimize interactions.

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Warnings

Paracetamol injection carries some important warnings that patients and medical professionals should be aware of.

Liver Toxicity:

Paracetamol can cause severe, and sometimes fatal, liver damage if too much is taken. This risk is increased if paracetamol is taken while drinking alcohol. Patients with liver disease should use paracetamol cautiously and only under medical supervision.

The maximum recommended daily dose of paracetamol is 4,000 mg per day for adults and 90 mg/kg for children. Exceeding this dose substantially increases the risk of liver toxicity. If liver toxicity occurs, it can present with nausea, vomiting, abdominal pain and jaundice. Immediate medical care is required.

Overdose Dangers:

Paracetamol overdose can lead to liver failure and death in severe cases. Overdose risk is increased when paracetamol is combined with other medicines like codeine or oxycodone.

Signs of paracetamol overdose include nausea, vomiting, loss of appetite, sweating, abdominal pain, and coma or seizures in later stages. Patients who suspect they've taken an overdose should seek emergency medical attention even if they feel fine, as damage can develop over the next 1-4 days.

Other Precautions:

• Paracetamol injection should only be administered by a doctor or nurse. It is not intended for self-administration.

• Use cautiously in patients with renal impairment, as paracetamol is eliminated by the kidneys. Dose reduction may be required.

• Paracetamol can temporarily decrease platelet function. Those with bleeding disorders should use with caution.

• Use cautiously in patients who regularly consume alcohol. Chronic heavy alcohol use is associated with increased paracetamol toxicity.

• Paracetamol injection contains sodium metabisulfite which can cause allergic reactions in sensitive people.

• Paracetamol injection is not recommended for use in pregnant women unless necessary. It crosses the placenta and long-term safety is not established.

Alternatives to Paracetamol Injection

Paracetamol injection is commonly used for treating pain and fever. However, there are times when an alternative medication or treatment method may be preferred.

Other Pain Relievers:

For acute pain relief, other options include:

• Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, naproxen, or diclofenac. These work by blocking prostaglandins that cause inflammation and pain.

• Opioid analgesics like morphine, codeine, oxycodone, or tramadol. These bind to opioid receptors in the brain to provide strong pain relief.

• Local anesthetics like lidocaine injections can numb specific pain sites.

Some of these alternatives may be more appropriate depending on the type or severity of pain. They can also be used in combination with paracetamol for enhanced pain relief. However, NSAIDs and opioids have more potential side effects like gastrointestinal bleeding or addiction risk.

Natural Alternatives:

Some patients may prefer natural remedies like:

• Heat or cold therapy for muscle aches.

• Acupuncture which may help relieve certain pain conditions.

• Herbal supplements like turmeric, ginger, or willow bark. However, dosing of these herbs can be inconsistent.

• Mind-body therapies like massage, physical therapy, or relaxation techniques to help manage pain.

While these don't treat the underlying cause, they can provide symptom relief and be used alongside other pain medications.

When Paracetamol May Not Be Suitable?

In some cases, paracetamol injection may not be the best option such as:

• Liver impairment or active liver disease - paracetamol is metabolized by the liver so high doses could potentially cause further liver toxicity.

• Alcohol dependence or chronic alcohol consumption - this increases the risk of liver toxicity.

• history of allergic reaction or hypersensitivity

• Severe acute pain like surgical pain or severe back pain where paracetamol alone may not provide sufficient relief.

Overall, alternatives to paracetamol injection provide other options for pain management based on the clinical scenario. Consulting a doctor can help determine the most appropriate pain reliever based on the individual's medical status, type of pain, risk factors, and need for adequate pain control.

FAQs About Paracetamol Injection 600mg
What is Paracetamol injection 600mg?

Paracetamol injection 600mg is an intravenous formulation of the common pain reliever and fever reducer paracetamol, also known as acetaminophen.

The injection comes in vials containing 600mg of paracetamol per 10mL solution. It is administered directly into the bloodstream through intravenous infusion.

Paracetamol injection 600mg provides a higher concentration and faster delivery method compared to oral paracetamol tablets. It allows patients who are unable to take medications by mouth, or require urgent symptom relief, to benefit from paracetamol's effects.

The injection is used for management of mild to moderate pain, and reduction of fever, when the intravenous route is clinically indicated. As an analgesic and antipyretic, it works by inhibiting prostaglandin synthesis in the body's central nervous system to block pain and reduce fever.

Paracetamol injection 600mg delivers the pain and fever relieving effects of paracetamol rapidly due to its IV administration. It provides an alternative delivery method when timely relief is needed and oral administration is not suitable.

What is paracetamol injection used for?

Paracetamol injection is used to treat mild to moderate pain, as well as to reduce fever. It can be used alone or in combination with other medications. The injection allows for faster pain and fever relief compared to oral paracetamol.

How is paracetamol injection administered?

Paracetamol injection is given intravenously, usually as a slow injection over 15 minutes. It should only be administered by a doctor or nurse.

The recommended dose for adults is 1 gram (1000mg) every 4 to 6 hours, up to a maximum of 4 grams per day.

How long does it take for paracetamol injection to work?

Paracetamol injection starts working within 5 to 10 minutes after administration. Pain relief lasts for approximately 4 to 6 hours.

What are the side effects of paracetamol injection?

Common side effects include nausea, vomiting, sweating and flushing. Rare but serious side effects include low blood cell counts and liver damage. Paracetamol injection is not recommended for people with liver disease.

Can paracetamol injection be used long-term?

Paracetamol injection is only intended for short-term use. It should not be used regularly for more than a few days due to the risk of liver toxicity. For long-term pain relief, other medications may be more appropriate.

Is paracetamol injection safe during pregnancy?

At recommended doses, paracetamol injection is considered safe for short-term use in pregnancy. High doses or prolonged use should be avoided as a precaution. Always consult a doctor before using any medication when pregnant.

How does paracetamol injection differ from oral paracetamol?

The injection works faster, provides higher blood concentrations, and does not rely on absorption through the digestive tract. This makes it useful when oral administration is not possible or fast pain relief is required. However, the injection may have more side effects.

Product Specifications:

paracetamol inj 600mg

SKU“stock keeping unit”:2024.par16001.

gtin14:20231111001003

Price:0.99 - 1.99$.

Price Currency: USD

Price Valid Until:"2026-11-20

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Volume:1ml.

Dosage:600mg.

Active Ingredients:paracetamol.

Specifications:BP;USP.

Packaging:Amp,5;10.

Product List - Liquid Injections

Product Name Strength
Vitamin B1 injection 100mg: 2ml
Vitamin B6 Injection 0.1g: 2ml
Vitamin B12 injection 0.5mg:1ml
VIT-B Complex injection 2ml
Tri B-inj B1-100mg+B2-100mg+B12-1000mcg 3ml
Vitamin C injection 0.5g:2ml
VITAMIN K1 injection 10mg:1ml
Dexamethasone Na phosphate injection 4mg: 1ml
Dexamethasone Na phosphate injection 8mg: 2ml
Diclofenac Sodium Injection 75mg:3ml
Metoclopramide hydrochloride injection 10mg:2ml
Metoclopramide hydrochloride injection 5mg:1ml
Iron Sucrose IV Injection 100mg:5ml
Iron Dextran Injection 100mg:2ml
Promethazine Hydrochloride Injection 50mg:2ml
Gentamycin sulfate injection 40mg:2ml
Gentamycin sulfate injection 80mg:2ml
Furosemide Injection 20mg:2ml
Aminophylline Injection 250mg:10ml
Paracetamol injection 150mg:1ml
Paracetamol injection 300mg:2ml
Paracetamol injection 500mg:4ml
Paracetamol injection 600mg:4ml
Paracetamol injection 750mg:5ml
Diazepam injection 5mg/1ml
Diazepam injection 10mg:2ml
Diazepam injection 5mg/1ml
Diazepam injection 10mg:2ml
Oxytocin Injection 5 iu/1ml
Oxytocin Injection 10 iu / 1ml
Chlorphenamine Maleate Injection 10mg:1ml
Hyoscine Butylbromide(Buscopan)Injection 20mg:1ml
Lidocaine Hydrochloride injection 10ml:0.2g
Methotrexate for Injection 50mg:2ml
ENOXAPARIN SODIUM Prefilled syringe 40MG/0.4ML
ENOXAPARIN SODIUM Prefilled syringe 60MG/0.6ML
ENOXAPARIN SODIUM Prefilled syringe 80MG/0.8ML
Adrenaline(Epinephrine HCL)Injection 1mg:1ml
Testosterone 250mg:1ml 250mg:1ml

Product List - Vial Injections

Product Name Strength
Omeprazol 40 mg IV VIAL 10ml or 5ml
Pantoprazole Sodium for Injection 40mg
Lansoprazole for Injection 30 mg
Ceftriaxone 1gm/10ml IV VIAL +10ml water
Ceftriaxone 1gm/10ml VIAL +Lidocain 1%
Ceftriaxone IM/IV VIAL 500mg/15 ml
Ampicillin Na VIAL 0.5 g/Vial
Ampicillin Na VIAL 1g/Vial
Cefotaxime Sodium for VIAL 1g/Vial
Ceftazidime For I.M/I.V VIAL 1g/Vial
Cefepime For I.M/I.V VIAL 1g/Vial
Meropenem VIAL Injection 1g/20ml/Vial
Procaine Penicillin(0.4mega/7ml) 400.000 U/7ml
Procaine Penicillin(0.6mega/7ml) 600.000 U/7ml
Procaine Penicillin(1.2mega/7ml) 800.000 U/7ml
Procaine Penicillin (0.8mega/7ml) 1200.000 U/7ml
Benzathine Penicillin for Injection 1.2mega/7ml
Vancomycin Hcl injection 500mg 500mg/Vial
Vancomycin Hcl injection 500mg 1g/Vial
Heparin Sodium Injection 5ml:5000 units
Heparin Sodium Injection 5ml:25000 units
Amoxicillin Na and Clavulanate Potassium for Inj(augmentin) G Powder 1.2
Amoxicillin Na and Clavulanate Potassium for Inj(augmentin) G Powder 0.6
lyophilized Hydrocortisone Na Succinate 3ml:0.1gm
aseptic lyophilized Hydrocortisone Na Succinate 7m:0.1gm
Phenobarbital Sodium Injection 1ml:0.1g
Piperacillin Sodium and Tazobactam Na for Inj 4.5g

Product List - IV INFUSION

Product Name Strength
Paracetamol 1G IV infusion 100ml glass bottle
Metronidazole 500mg IV infusion 100ml glass bottle
Ciprofloxacine 200mg IV infusion 20ml plastic bottle
0.9% Na Chloride IV Inj 500ml plastic bottle
5% Glucose Injection 250ml:12.5g,500ml:25g
10% Glucose Injection 250ml:12.5g,500ml:25g
Sodium Lactate Ringer`s Inj 500ml Plastic Bottle
5% Glu + 0.9% Na Chlorid inj 250ml: Glu 12.5g,NaCl 2.25g
5% Glu + 0.9% Na Chlorid inj 500ml: Glu 25g,NaCl 4.5g
10% Glu + 0.9% Na Chlorid inj 250ml: Glu 25g,NaCl 2.25g
10% Glu + 0.9% Na Chlorid inj 500ml: Glu 50g,NaCl 4.5g
Mannitol injection 250ml:50g P Bottle

Product List - SYRUP

Product Name Strength
Amoxicillin 125mg + Clavulanic Acid 31.5mg 100 ml glass Bottle
Amoxicillin 250mg + Clavulanic Acid 62.5mg 100 ml glass Bottle
Amoxicillin 400mg + Clavulanic Acid 75mg 100 ml glass Bottle
Azithromycine 100mg 15ml 1bottle/Box
Metronidazole 125mg 100 ml glass Bottle
Metronidazole 250mg 100 ml glass Bottle
Amoxicillin 125 mg 100 ml glass Bottle
Amoxicillin 250 mg 100 ml glass Bottle
Paracetamol syrup 250mg/5ml 250mg/5ml syrup
Ibuprofen Dry Suspension 100mg/5ml 100ml Suspension

Product List - TABLETS

Product Name Strength
Azithromycine 500mg Tab(3 tabs) 3 tablets X 1 blister
Metronidazole 500mg Tab(14 tabs) 7 tablets X 2 blisters
Ciprofloxacine 500mg TAB(10 tabs) 10 tablets X 1 blister
Amoxicillin 250mg + Clavulanic Acid 125mg(14 tabs) 7 tablets x 2 blister
Amoxicillin 500mg + Clavulanic Acid 125mg(14 tabs) 7 tablets x 2 blister
Amoxicillin 875mg + Clavulanic Acid 125mg(14 tabs) 7 tablets x 2 blister
Nitrofurantoin 100mg Tablets 10 tablets X 1 blister
Aspirin Enteric-coated 500mg 10 tablets X 1 blister
Paracetamol 500mg 10 tablets X 1 blister
Ibuprofen 400mg 10 tablets X 1 blister
Diclofenac Na 400mg 10 tablets X 1 blister
Diclofenac 50mg + Paracetamol 500mg 10 tablets X 1 blister
Folic acid 5mg Tab 10 tablets X 1 blister
Ciprofloxacin Tablets 10 tablets X 1 blister
Doxycycline 100mg Tab 10 tablets X 1 blister
Meloxicam 15mg Tab 10 tablets X 2 blisters
Fluconazole 150mg Tab 10 tablets X 2 blisters
Simvastatin 40mg Tab 10 tablets X 2 blisters
Prednisolone 5mg Tab 10 tablets X 2 blisters
Spiramycin 750,000 unit Tab 10 tablets X 2 blisters
Spiramycin 1,500,000 unit Tab 10 tablets X 2 blisters

Product List - CAPSULES

Product Name Strength
Amoxicillin 500mg(16 Capsules) 8 cap X 2 blisters
Ampicillin Capsules 10 cap X 2 blisters
Cloxacillin Na Capsules 10 cap X 2 blisters
Piroxicam Capsule 10 cap X 2 blisters
Tetracyline 250 mg Capsule 10 cap X 2 blisters
Oxytetracycline 250mg Capsule 10 cap X 2 blisters
Spiramycin 375,000 unit Cap 10 cap X 2 blisters
Indomethacin 25mg Capsule 10 cap X 2 blisters

Product List - Suppository

Product Name Strength
Paracetamol 125mg suppository 5 Supp x 2 blister
Paracetamol 250mg suppository 5 Supp x 2 blister
Policresulen Vaginal 90mg Suppository 4 Supp x 2 blister
Chlorhexidine Acetate 20mg Supp 5 Supp x 2 blister
Miconazole Nitrate Vaginal 100mg Supp 5 Supp x 2 blister
Clotrimazole Vaginal 150mg Supp 5 Supp x 2 blister
Metronidazole Vaginal 500mg Supp 5 Supp x 2 blister
Indomethacin 500mg Supp 5 Supp x 2 blister