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Paracetamol injection 500mg: overview

Paracetamol 500 mg Injection is an intravenous version of the common pain reliever paracetamol (also known as acetaminophen).

is prescribed to treat mild to severe pain and reduce fever. Paracetamol injection works by blocking the synthesis of prostaglandins in the brain and spinal cord that transmit pain signals. It crosses the blood-brain barrier, works intensively, and lowers body temperature.

Paracetamol Injection is used when oral administration is not possible, such as before or after surgery, or when the patient is nauseated or vomiting. The analgesic and antipyretic effects occur more quickly than oral paracetamol. Intravenous administration increases bioavailability and avoids hepatic metabolism.

Hospitals and clinics administer paracetamol when needed to provide rapid, strong analgesia/fever reduction. It is usually given before and after surgery to relieve pain and fever.

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Acetaminophen Injection Uses 500mg

Acetaminophen Injection is used to treat mild to moderate pain and reduce fever. Doctors may prescribe paracetamol injections for the following reasons:

Post-operative pain management - Paracetamol injections are often used after surgery to relieve severe pain and avoid opioid-induced illness. It helps provide effective pain relief when patients are unable to take oral medications.

Reduce fever - Paracetamol injections can quickly reduce fevers such as infections, inflammation or immune reactions. It is an antipyretic.

Migraines and Headaches - For severe headaches or migraines, injectable paracetamol can provide immediate relief when oral paracetamol doesn't work.

Musculoskeletal Pain - Paracetamol may be given by injection to treat severe pain caused by arthritis, rheumatism, arthritis and other musculoskeletal conditions (injections are used as oral medications).

Kidney or gallstones - Some doctors prescribe injectable paracetamol as part of multidisciplinary treatment for kidney or gallstones.

Cancer Complications - Treatment with paracetamol may be used when oral administration is not possible or possible.

The main reason doctors choose paracetamol injection over other pain relievers is its low and no side effects compared to nonsteroidal anti-inflammatory drugs and opioids. Fever and pain can be effective if treated properly.

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Dosage Information

Paracetamol injection is usually given intravenously. The recommended dose for adults is 1 gram every 4 to 6 hours, increasing by 4 grams over 24 hours.

In elderly patients, patients with liver disease, and the elderly weighing less than 50 kg, it is recommended to reduce the dose to 500-1000 mg every 4-6 hours. The maximum dose should not exceed 60 mg/kg per day.

Paracetamol injections are not recommended for children under 10 kg. For children weighing between 10-50 kg, the recommended dose is 15 mg/kg, with a maximum of 60 mg/kg per day.

As the patient improves, the duration of the dose should be increased. Intravenous paracetamol should be administered over 15 minutes and diluted in intravenous fluids if necessary.

Paracetamol should not be administered to patients with severe liver disease due to hepatotoxicity. Patients with renal impairment may also require a dose reduction.

Healthcare providers should monitor liver function and watch for signs of overdose, including nausea, vomiting, and right-sided abdominal pain.

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Administration

Paracetamol injection is administered intravenously, usually by intravenous injection. It should be provided by a doctor or nurse in a hospital or clinic.

The adult dose is 1 g administered slowly over 15 minutes every 4-6 hours, up to a maximum of 4 g daily. It is supplied as a ready-to-use solution in 10mL vials at a concentration of 10mg/mL. Before intravenous administration, the required dose is diluted with 50-100 mL of compatible diluent.

Paracetamol Injection has been shown to be compatible with common infusion solutions such as normal saline, 5% dextrose, and lactated Ringer's solution. But it should not be mixed with other drugs at the same time. Acetaminophen injection should be administered on a separate infusion schedule.

Vital signs such as blood pressure, heart rate, respiration, and body temperature should be monitored during the infusion. All infusion-related procedures should be read immediately.

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Paracetamol Injection 500mg Side Effects

Paracetamol Injection can cause severe pain when taken internally. Analgesia occurs within 5 to 10 minutes of administration.

The protective effect of a single dose of paracetamol usually lasts for 4 to 6 hours, after which the analgesic effect diminishes and the next dose can be given if needed.

The most common side effects of acetaminophen injection are:

Nausea and vomiting - up to 1 in 10 people may experience this. Nausea may be worse when acetaminophen is given rapidly through an IV.

Inhalation - Redness of the face and neck is a common side effect.

Sweating - Sometimes heavy sweating occurs immediately after an injection.

Hypotension - A slight drop in blood pressure immediately after a paracetamol injection. This is only temporary.

Injection site pain - Pain, stinging, or burning sensation at the injection site. These are simple and go quickly.

Side effects are rare. An allergic reaction to acetaminophen injections is unlikely, but may cause symptoms such as flushing, itching, wheezing, and difficulty breathing. In some cases, liver damage occurs as a result of taking too much paracetamol.

Precautions

Injectable paracetamol, like oral paracetamol, should be used with caution in patients with:

Hepatic impairment or severe liver disease - Paracetamol is metabolized by the liver, thereby increasing the risk of paracetamol accumulation and liver damage. . . Low dosage is recommended.

Drinking alcohol - Drinking alcohol can activate liver enzymes and increase the metabolism of acetaminophen, making it toxic. This increases the risk of liver disease. Limit alcohol intake while taking acetaminophen.

Renal Impairment - In renal impairment, the production of paracetamol metabolites is reduced and the risk of accumulation is increased. Depending on renal function, dose reduction may be necessary.

G6PD Deficiency - Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency are at increased risk of red blood cell damage when taking acetaminophen.

Pregnancy and Breastfeeding - Paracetamol has been shown to be safe during pregnancy when used at normal doses. Please consult your doctor before use. Caution is recommended during long-term use during pregnancy.

Elderly patients - The elderly are more susceptible to poisoning. Consider using lower doses in elderly or frail patients.

Paracetamol Injection should not be used in patients with:

Known hypersensitivity or intolerance to paracetamol

Severe acute illness

Possible drug interactions:

Anticonvulsant paracetamol

Check carefully after injecting paracetamol. Health care providers should perform laboratory testing and evaluate toxicity and side effects.

Laboratory examinations and tests

Liver examinations should be performed before and during treatment. High doses of paracetamol can cause liver damage.

Renal function and electrolytes should be monitored because acetaminophen is broken down by the kidneys. Kidney damage increases the risk of acetaminophen ingestion and liver damage.

In critically ill patients, blood paracetamol concentrations should be determined. The therapeutic dose range is 10-20 mcg/mL. Higher levels indicate increased inflammation and a higher risk of liver disease.

Comparisons with Other Treatments

Paracetamol injection is most commonly used for the treatment of fever and mild-to-moderate pain. It can be compared to other common medications used for these purposes:

• NSAIDs (non-steroidal anti-inflammatory drugs) - NSAIDs like ibuprofen (Advil, Motrin) and naproxen (Aleve) are also used to treat fever and pain. Unlike paracetamol, NSAIDs also have anti-inflammatory effects. However, NSAIDs have more potential side effects like stomach ulcers or bleeding, high blood pressure, kidney problems, and increased risk of heart attack or stroke. Paracetamol is usually preferred over NSAIDs in people with these conditions.

• Opioid pain medications - Opioids like morphine, oxycodone, and codeine are stronger pain medications sometimes used for moderate-to-severe pain. While more potent for pain relief, opioids have risks of addiction, overdose, and side effects like drowsiness, constipation, and slowed breathing. Paracetamol is not addictive and is safer for most people.

• Acetaminophen oral tablets - Paracetamol injection provides faster pain relief compared to oral acetaminophen tablets. However, oral tablets may be appropriate for milder pain or fever. The injection would be used when a patient cannot take oral medication or rapid onset is needed.

• IV morphine - For severe acute pain like trauma, heart attacks, or postoperative pain, IV morphine may be used instead of paracetamol injection. However, morphine has more side effects and monitoring requirements. Paracetamol injection can be used in combination with opioids like morphine to enhance pain control.

So in summary, paracetamol injection offers fever/pain reduction without risks of NSAID side effects, opioid addiction, or oral medication issues. It can be used alone or combined with other agents depending on the clinical scenario.

What is Paracetamol Injection 500mg?

Paracetamol 500 mg Injection is an intravenous version of the common pain reliever paracetamol (also known as acetaminophen).

is prescribed to treat mild to severe pain and reduce fever. Paracetamol injection works by blocking the synthesis of prostaglandins in the brain and spinal cord that transmit pain signals. It crosses the blood-brain barrier, works intensively, and lowers body temperature.

Paracetamol Injection is used when oral administration is not possible, such as before or after surgery, or when the patient is nauseated or vomiting. The analgesic and antipyretic effects occur more quickly than oral paracetamol. Intravenous administration increases bioavailability and avoids hepatic metabolism.

Hospitals and clinics administer paracetamol when needed to provide rapid, strong analgesia/fever reduction. It is usually given before and after surgery to relieve pain and fever.

What is paracetamol used for?

Symptoms of Poisoning

Patients receiving paracetamol injections should be monitored for:

Nausea, vomiting, sweating and loss of appetite - the first symptoms of paracetamol poisoning.

Abdominal pain, diarrhea, yellowing of skin/eyes - symptoms of liver disease.

Changes in urine output, blood in urine - signs of kidney damage.

Confusion, sleep, unconsciousness.

Shortness of breath, blue lips/nails - lung/heart disease risk.

If symptoms of poisoning occur, paracetamol injection should be stopped immediately and liver function should be monitored. Acetylcysteine can be taken to prevent liver damage. If symptoms are severe, seek emergency medical care.

When to Seek Medical Advice?

Paracetamol injection is generally safe when used as directed. However, there are some signs and symptoms to look out for that may indicate a more serious reaction.

Signs to Look Out For

Contact your doctor immediately if you experience any of the following after receiving paracetamol injection:

• Rash, hives, or itching

• Swelling of the face, throat, tongue, lips, or eyes

• Hoarseness or difficulty breathing or swallowing

• Unusual bruising or bleeding

• Signs of liver problems like dark urine, yellowing eyes/skin, stomach pain, or nausea

These could be signs of an allergic reaction or other adverse effect that requires prompt medical care. Do not ignore or wait to see if symptoms resolve on their own.

When to Call a Doctor?

In addition to the above symptoms, call your doctor if you experience:

• Persistent nausea, vomiting, or loss of appetite

• Stomach pain that does not go away

• Headaches that do not resolve after treatment

• Ongoing fever or flu-like symptoms

• Depression or confusion

• Ringing in the ears or changes in hearing

• Seizures

Unrelenting side effects or new symptoms that arise during or after treatment with paracetamol injection need medical evaluation. Do not try to self-manage side effects without speaking to your healthcare provider.

Calling a doctor promptly at the first sign of a potential reaction or side effect can help prevent complications. Follow your provider's recommendations regarding any symptoms after receiving paracetamol injection.

Registration:

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Product Specifications:

paracetamol inj 500mg

SKU“stock keeping unit”:2024.par15001.

gtin14:20231111001002

Price:0.95 - 1.99$.

Price Currency: USD

Price Valid Until:"2026-11-20

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paracetamol inj 500mg

Volume:1ml.

Dosage:500mg.

Active Ingredients:paracetamol.

Specifications:BP;USP.

Packaging:Amp,5;10.

Product List - Liquid Injections

Product Name Strength
Vitamin B1 injection 100mg: 2ml
Vitamin B6 Injection 0.1g: 2ml
Vitamin B12 injection 0.5mg:1ml
VIT-B Complex injection 2ml
Tri B-inj B1-100mg+B2-100mg+B12-1000mcg 3ml
Vitamin C injection 0.5g:2ml
VITAMIN K1 injection 10mg:1ml
Dexamethasone Na phosphate injection 4mg: 1ml
Dexamethasone Na phosphate injection 8mg: 2ml
Diclofenac Sodium Injection 75mg:3ml
Metoclopramide hydrochloride injection 10mg:2ml
Metoclopramide hydrochloride injection 5mg:1ml
Iron Sucrose IV Injection 100mg:5ml
Iron Dextran Injection 100mg:2ml
Promethazine Hydrochloride Injection 50mg:2ml
Gentamycin sulfate injection 40mg:2ml
Gentamycin sulfate injection 80mg:2ml
Furosemide Injection 20mg:2ml
Aminophylline Injection 250mg:10ml
Paracetamol injection 150mg:1ml
Paracetamol injection 300mg:2ml
Paracetamol injection 500mg:4ml
Paracetamol injection 600mg:4ml
Paracetamol injection 750mg:5ml
Diazepam injection 5mg/1ml
Diazepam injection 10mg:2ml
Diazepam injection 5mg/1ml
Diazepam injection 10mg:2ml
Oxytocin Injection 5 iu/1ml
Oxytocin Injection 10 iu / 1ml
Chlorphenamine Maleate Injection 10mg:1ml
Hyoscine Butylbromide(Buscopan)Injection 20mg:1ml
Lidocaine Hydrochloride injection 10ml:0.2g
Methotrexate for Injection 50mg:2ml
ENOXAPARIN SODIUM Prefilled syringe 40MG/0.4ML
ENOXAPARIN SODIUM Prefilled syringe 60MG/0.6ML
ENOXAPARIN SODIUM Prefilled syringe 80MG/0.8ML
Adrenaline(Epinephrine HCL)Injection 1mg:1ml
Testosterone 250mg:1ml 250mg:1ml

Product List - Vial Injections

Product Name Strength
Omeprazol 40 mg IV VIAL 10ml or 5ml
Pantoprazole Sodium for Injection 40mg
Lansoprazole for Injection 30 mg
Ceftriaxone 1gm/10ml IV VIAL +10ml water
Ceftriaxone 1gm/10ml VIAL +Lidocain 1%
Ceftriaxone IM/IV VIAL 500mg/15 ml
Ampicillin Na VIAL 0.5 g/Vial
Ampicillin Na VIAL 1g/Vial
Cefotaxime Sodium for VIAL 1g/Vial
Ceftazidime For I.M/I.V VIAL 1g/Vial
Cefepime For I.M/I.V VIAL 1g/Vial
Meropenem VIAL Injection 1g/20ml/Vial
Procaine Penicillin(0.4mega/7ml) 400.000 U/7ml
Procaine Penicillin(0.6mega/7ml) 600.000 U/7ml
Procaine Penicillin(1.2mega/7ml) 800.000 U/7ml
Procaine Penicillin (0.8mega/7ml) 1200.000 U/7ml
Benzathine Penicillin for Injection 1.2mega/7ml
Vancomycin Hcl injection 500mg 500mg/Vial
Vancomycin Hcl injection 500mg 1g/Vial
Heparin Sodium Injection 5ml:5000 units
Heparin Sodium Injection 5ml:25000 units
Amoxicillin Na and Clavulanate Potassium for Inj(augmentin) G Powder 1.2
Amoxicillin Na and Clavulanate Potassium for Inj(augmentin) G Powder 0.6
lyophilized Hydrocortisone Na Succinate 3ml:0.1gm
aseptic lyophilized Hydrocortisone Na Succinate 7m:0.1gm
Phenobarbital Sodium Injection 1ml:0.1g
Piperacillin Sodium and Tazobactam Na for Inj 4.5g

Product List - IV INFUSION

Product Name Strength
Paracetamol 1G IV infusion 100ml glass bottle
Metronidazole 500mg IV infusion 100ml glass bottle
Ciprofloxacine 200mg IV infusion 20ml plastic bottle
0.9% Na Chloride IV Inj 500ml plastic bottle
5% Glucose Injection 250ml:12.5g,500ml:25g
10% Glucose Injection 250ml:12.5g,500ml:25g
Sodium Lactate Ringer`s Inj 500ml Plastic Bottle
5% Glu + 0.9% Na Chlorid inj 250ml: Glu 12.5g,NaCl 2.25g
5% Glu + 0.9% Na Chlorid inj 500ml: Glu 25g,NaCl 4.5g
10% Glu + 0.9% Na Chlorid inj 250ml: Glu 25g,NaCl 2.25g
10% Glu + 0.9% Na Chlorid inj 500ml: Glu 50g,NaCl 4.5g
Mannitol injection 250ml:50g P Bottle

Product List - SYRUP

Product Name Strength
Amoxicillin 125mg + Clavulanic Acid 31.5mg 100 ml glass Bottle
Amoxicillin 250mg + Clavulanic Acid 62.5mg 100 ml glass Bottle
Amoxicillin 400mg + Clavulanic Acid 75mg 100 ml glass Bottle
Azithromycine 100mg 15ml 1bottle/Box
Metronidazole 125mg 100 ml glass Bottle
Metronidazole 250mg 100 ml glass Bottle
Amoxicillin 125 mg 100 ml glass Bottle
Amoxicillin 250 mg 100 ml glass Bottle
Paracetamol syrup 250mg/5ml 250mg/5ml syrup
Ibuprofen Dry Suspension 100mg/5ml 100ml Suspension

Product List - TABLETS

Product Name Strength
Azithromycine 500mg Tab(3 tabs) 3 tablets X 1 blister
Metronidazole 500mg Tab(14 tabs) 7 tablets X 2 blisters
Ciprofloxacine 500mg TAB(10 tabs) 10 tablets X 1 blister
Amoxicillin 250mg + Clavulanic Acid 125mg(14 tabs) 7 tablets x 2 blister
Amoxicillin 500mg + Clavulanic Acid 125mg(14 tabs) 7 tablets x 2 blister
Amoxicillin 875mg + Clavulanic Acid 125mg(14 tabs) 7 tablets x 2 blister
Nitrofurantoin 100mg Tablets 10 tablets X 1 blister
Aspirin Enteric-coated 500mg 10 tablets X 1 blister
Paracetamol 500mg 10 tablets X 1 blister
Ibuprofen 400mg 10 tablets X 1 blister
Diclofenac Na 400mg 10 tablets X 1 blister
Diclofenac 50mg + Paracetamol 500mg 10 tablets X 1 blister
Folic acid 5mg Tab 10 tablets X 1 blister
Ciprofloxacin Tablets 10 tablets X 1 blister
Doxycycline 100mg Tab 10 tablets X 1 blister
Meloxicam 15mg Tab 10 tablets X 2 blisters
Fluconazole 150mg Tab 10 tablets X 2 blisters
Simvastatin 40mg Tab 10 tablets X 2 blisters
Prednisolone 5mg Tab 10 tablets X 2 blisters
Spiramycin 750,000 unit Tab 10 tablets X 2 blisters
Spiramycin 1,500,000 unit Tab 10 tablets X 2 blisters

Product List - CAPSULES

Product Name Strength
Amoxicillin 500mg(16 Capsules) 8 cap X 2 blisters
Ampicillin Capsules 10 cap X 2 blisters
Cloxacillin Na Capsules 10 cap X 2 blisters
Piroxicam Capsule 10 cap X 2 blisters
Tetracyline 250 mg Capsule 10 cap X 2 blisters
Oxytetracycline 250mg Capsule 10 cap X 2 blisters
Spiramycin 375,000 unit Cap 10 cap X 2 blisters
Indomethacin 25mg Capsule 10 cap X 2 blisters

Product List - Suppository

Product Name Strength
Paracetamol 125mg suppository 5 Supp x 2 blister
Paracetamol 250mg suppository 5 Supp x 2 blister
Policresulen Vaginal 90mg Suppository 4 Supp x 2 blister
Chlorhexidine Acetate 20mg Supp 5 Supp x 2 blister
Miconazole Nitrate Vaginal 100mg Supp 5 Supp x 2 blister
Clotrimazole Vaginal 150mg Supp 5 Supp x 2 blister
Metronidazole Vaginal 500mg Supp 5 Supp x 2 blister
Indomethacin 500mg Supp 5 Supp x 2 blister